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Tuesday, August 4, 2020 | History

1 edition of Production and use of interferon for the treatment and prevention of human virus infections found in the catalog.

Production and use of interferon for the treatment and prevention of human virus infections

Production and use of interferon for the treatment and prevention of human virus infections

proceedings of a Tissue Culture Association workshop held at the W. Alton Jones Cell Science Center, Lake Placid, New York, May 1973.

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  • 23 Currently reading

Published by Tissue Culture Association in Rockville, Md .
Written in English

    Subjects:
  • Virus diseases -- Congresses.,
  • Interferon -- Congresses.,
  • Interferon -- Congresses.,
  • Virus diseases -- Prevention and control -- Congresses.,
  • Virus diseases -- Therapy -- Congresses.

  • Edition Notes

    Includes bibliographical references.

    StatementWarren R. Stinebring, convenor; Charity Waymouth, editor.
    SeriesIn vitro. Monograph, no. 3
    ContributionsStinebring, Warren R., Waymouth, Charity, ed., Tissue Culture Association.
    Classifications
    LC ClassificationsRC114.5 .P69
    The Physical Object
    Pagination74 p.
    Number of Pages74
    ID Numbers
    Open LibraryOL5051562M
    LC Control Number74013026

    Vaccines for Prevention. The primary method of controlling viral disease is by vaccination, which is intended to prevent outbreaks by building immunity to a virus or virus family (Figure ). Vaccines may be prepared using live viruses, killed viruses, or molecular subunits of the virus. Note that the killed viral vaccines and subunit viruses are both incapable of causing disease, nor is. Eligible patients were randomly assigned in a ratio to receive alemtuzumab (at a dose of either 12 mg per day or 24 mg per day) or interferon beta-1a with the use of the Pocock and Simon.

    Another way of treating viral infections is the use of antiviral drugs. Because viruses use the resources of the host cell for replication and the production of new virus proteins, it is difficult to block their activities without damaging the host. However, we do have some effective antiviral drugs, such as those used to treat HIV and influenza. Cantell K, Hirvonen S, Mogensen KE, et al: Human leukocyte interferon: Production, purification, stability, and animal experiments, in Waymouth C (ed): The Production and Use of Interferon for the Treatment and Prevention of Human Virus Infections In Vitro, monograph No. 3. Rockville, Md, Tissue Culture Association, , pp

      Interferon-alpha (interferon-alfa): treats viral infections like hepatitis C; Interferon-beta: treats different types of multiple sclerosis; Interferon-gamma: treats chronic granulomatous disease and malignant osteopetrosis; Interferon treatment consists of synthetic versions of the proteins that are normally created by the body but instead. INFα and INFβ are produced by virus infected fibroblasts. Virus infected leukocytes, antigen stimulated T cells and natural killer cells can produce INFγ. Interferon Production is Triggered by Viral Infection. The synthesis and release of interferons form a cell is induced by the viral particles.


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Production and use of interferon for the treatment and prevention of human virus infections Download PDF EPUB FB2

The Production and use of interferon for the treatment and prevention of human virus infections; proceedings of a Tissue Culture Association workshop held at the W.

Alton Jones Cell Science Center, Lake Placid, New York, May One of the earliest symposia held at the Center was one concerned with Interferon, (Waymouth, C. (Ed.) The Production and Use of Interferon for the Treatment and Prevention of Human Virus Infections.

In Vitro, Monograph No. Tissue Culture Association, Rockville, Maryland.). Human Interferon: Production And Clinical Use (Advances In Experimental Medicine And Biology): Medicine & Health Science Books @ Havell, EA and Vilcek, J. (): Mass Production and Some Characteristics of Human Interferon from Diploid Cells.

In: Production and Use of Interferon for the Treatment and Prevention of Human Virus Infections, Waymouth, C., Ed., Rockville, MD: Tissue Culture Association, In Vitro, Monograph #3: Google ScholarCited by: 6.

Diseases. Interferon beta-1a and interferon beta-1b are used to treat and control multiple sclerosis, an autoimmune treatment may help in reducing attacks in relapsing-remitting multiple sclerosis and slowing disease progression and activity in secondary progressive multiple sclerosis.

Interferon therapy is used (in combination with chemotherapy and radiation) as a treatment for InterPro: IPR   Cariteli K, Hirvonen S, Mogensen K E, et al. Human leukocyte interferon: Production, purification, stability, and animal experiments.

The production and use of interferon for the treatment and prevention of human virus infections. Edited by C. Waymouth. Rockville, Tissue Culture Association,pp 35– Google Scholar. Interferon beta-1a, currently in use to treat multiple sclerosis, and interferon alfa-2b are both under investigation as potential treatments for people with COVID coronavirus disease, the deadly respiratory pandemic caused by the SARS-nCoV-2 virus.

Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. Interferon was named for its ability to interfere with viral proliferation.

The various forms of interferon are the body’s most rapidly produced and important defense against viruses. Interferons can also combat bacterial and parasitic infections, inhibit cell division, and promote or impede the differentiation of cells. They are produced by. When treatment with interferon in tissue culture was found to inhibit chronic infections with mouse leukaemia viruses, it seemed reasonable to try to treat chronic virus infections in patients with interferons, and indeed clinical studies employing IFN-α in chronic hepatitis B virus (HBV) infections yielded very promising results.

The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to.

Interferon, a product of mammalian tissues, was originally described as an antiviral agent over twenty years ago. Only in the past few years has evidence started to accumulate that interferon actually played a role in vivo in natural virus infections.

Initially, evidence was accumulated showing that interferon could inhibit the replication of many viruses in vitro. J.J. Graber, S.

Dhib-Jalbut, in Encyclopedia of the Neurological Sciences (Second Edition), Abstract. Interferons (IFNs) are proteins produced by a variety of cells in the inflammatory response to infections.

Their production is triggered by the immune system in response to pathogens or cytokines. Once triggered, they induce numerous molecular changes that affect cellular responses.

The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).

Treating Hepatitis With Interferon. Interferon is a powerful drug used to treat hepatitis types B, C, and D. It can prevent serious liver damage, but it also has many side effects, some of them.

The genus Flavivirus contains over 70 virus species, of which many cause disease in humans. Severe flavivirus infections are primarily characterized by encephalitic or hemorrhagic symptoms. Mortality rates vary, depending on the infecting virus species, from 1 to 2% (e.g., for the Central European encephalitis virus) up to 30 to 40% (e.g., for the Japanese encephalitis virus and the Russian.

Cancer Research UK: "Interferon (Intron A)," "Side Effects of Interferon (Intron A)." Clinical and Experimental Hepatology: "Recommendations for the treatment of hepatitis C in ".

Interferon alphas are used to treat viral infections (chronic hepatitis, human papillomavirus) and treating cancer (hairy cell leukemia, AIDS related - Kaposi sarcoma, malignant melanoma).

Interferon betas are used to treat or slow down the progression of multiple sclerosis. Interferon gamma is used to treat chronic granulomatous disease.

Treatment of the Burkitt lymphoma-derived cell line Daudi with highly purified human interferon-alpha (IFN-alpha) increased up to fold the number of cells expressing Epstein-Barr virus (EBV. Mycobacterium bovis BCG induces a characteristic Th1-type immune response upon infection of the host macrophages (15, 30).Among the Th1 cytokines that are induced by BCG infection, gamma interferon (IFN-γ) plays a major role in the activation of cell-mediated immunity (7, 9, 16, 20, 39).Because of its strong immunostimulatory properties, BCG treatment may have profound effects on the outcome.

Strander H, Cantrell K: Studies on antiviral and antitumor effects of human leukocyte interferon in vitro and in vivo, in Waymouth C (ed): The Production and Use of Interferon in the Treatment and Prevention of Human Virus Infections. Rockville, Md, The Tissue Culture Association.

Immune system - Immune system - Interferons: Another group of proteins that provide protection are the interferons, which inhibit the replication of many—but not all—viruses. Cells that have been infected with a virus produce interferon, which sends a signal to other cells of the body to resist viral growth.

When first discovered ininterferon was thought to be a single substance.Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causing coronavirus disease (COVID‐19) is the biggest pandemic of our lifetime to date.

No effective treatment i.Explore the latest full-text research PDFs, articles, conference papers, preprints and more on INTERFERON. Find methods information, sources, references or conduct a literature review on INTERFERON.